A topological tie-in

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Topological Interrogation and Editing (TIE)

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VASCULAR BIOLOGY A noncoding antisense RNA in tie-1 locus regulates tie-1 function in vivo

1Department of Pediatrics, Medical College of Wisconsin, Developmental Vascular Biology Program, Children’s Research Institute, Milwaukee; 2Biozentrum der Universität Basel, Basel, Switzerland; 3Pediatric Surgery, Translational and Biomedical Research Center, Children’s Research Institute, Milwaukee, WI; 4University of Chicago, Biological Sciences Division, IL; and 5Pediatric Pathology, Childre...

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Recently, messenger RNAs in eukaryotes have shown to associate with antisense (AS) transcript partners that are often referred to as long noncoding RNAs (lncRNAs) whose function is largely unknown. Here, we have identified a natural AS transcript for tyrosine kinase containing immunoglobulin and epidermal growth factor homology domain-1 (tie-1), tie-1AS lncRNA in zebrafish, mouse, and humans. I...

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ژورنال

عنوان ژورنال: Nature

سال: 1994

ISSN: 0028-0836,1476-4687

DOI: 10.1038/368103a0